In addition to these conventional sites of mitochondrial ROS generation, it has been recently reported that the branched-chain 2-oxoacid dehydrogenase (BCKDH) complex in mitochondria can produce superoxide and H 2 O 2 at higher rates than complex I from mitochondria (Quinlan et al., 2014)
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Tomic et al
Rima KaddurahDaouk is a coinventor on a series of patents in the metabolomics field
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This oxidative stress links to many diseases, including diabetes, obesity, Parkinsons, cystic fibrosis, cancer and heart problems