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To understand why, you have to start with the structural problem that defined every Blues conversion attempt of the 1990s

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Within the next decade, however, it would not be surprising to witness the integration of standardized pharmacological neoadjuvant or targeted adjuvant therapies, with definitive surgical managementnot only for tumors that are metastatic or non-resectable but as a matter of course to minimize pre-operative disease burden

Compared with people starting topiramate, those starting GLP-1 drugs were 48% less likely to start valproate, 42% less likely to start calcitonin gene-related peptide (CGRP) monoclonal antibodies, 35% less likely to start tricyclic antidepressants, and 23% less likely to start the class of drugs called gepants

doi: 10.1002/edm2.9 132 WernerE.BellJ