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The core feature of the CPP model is its ability to specifically isolate the rewarding effects of drugs, making it the gold standard for evaluating substance addictive potential and cue-induced drug-seeking behavior

This minimizes the glucose or blood sugar in the body

This effect was previously documented in the DCCT and UKPDS trials and occurs regardless of the treatment method used (insulin, oral agents, or GLP-1 medications), reflecting changes in retinal blood flow and vascular permeability during metabolic adjustment

Over 8 weeks, flexible-dose pioglitazone (1545 mg/day) showed no significant differences compared with placebo in clinical response, remission rates, or changes in depressive symptom severity, measured using the Inventory of Depressive Symptomatology Clinician Rated (IDS-C30)

Recovery time required

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