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Iatrogenic iron promotes neurodegeneration and activates self-protection of neural cells against exogenous iron attacks

Second, mouse strains expressing disease-causing VCP mutants and those lacking ULK1/2 expression in muscle both develop a vacuolar myopathy with ubiquitin+/SQSTM1+/TDP43+ inclusions, similar to that observed in patients with IBM ( 33 , 35 37 )

The baseline diets and metabolic profiles are very different between Asian and Western populations (159)