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They can be used safely all over the body

In animal cells the fate of ITCs is well characterized: conjugation to glutathione by GSTs resulting in its intracellular depletion and subsequent degradation of dithiocarbamates through enzymatic events catalysed by -glutamyltranspeptidase, cysteinylglycinase and N -acetyltransferase via the mercapturic acid pathway 76

Galindo is supported in part by grants from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institute of Health (NIH) under award numbers P30DK111024, 1K23DK123384, 1R03DK138255, and 1U2CDK137135

At the same time, GIP peptide concentrations do not change with fasting or feeding (Higashimoto et al., 1995), suggesting that synthesis and secretion are relatively synchronized