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In addition to serving as a substrate for protein synthesis, Trp is metabolized through the Kyn pathway via IDO1/tryptophan 2,3-dioxygenase (TDO) to generate metabolites such as Kyn, which can influence inflammatory transcription and immune tolerance through signaling axes such as the AhR ( In the immune microenvironment, Trp can enter the Kyn pathway through IDO1 or TDO, generating Kyn and its downstream metabolites

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10.1161/01.str.0000217404.64352.d7 Summary Keywords AT1 receptor, oxidative stress, angiogeneis, amphetamine, glia, working memory, short-term memory, prefrontal cortex Citation Basmadjian OM, Occhieppo VB, Marchese NA, Silvero C

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