The C5 domain of nocardicin NRPS (NocB) not only fulfills its canonical function by forming the corresponding amide bond in the growing peptide chain, but also mediates cyclization of the beta lactam ring 29
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Interestingly, PNPLA3 I148M is not properly targeted by the UPS which likely promotes the disease-causing variant to accumulate on LDs (135) where it can disrupt protein-protein interactions critical for TAG hydrolysis (70, 75)