It has been well established that GLP-1 RA is associated with improved glucose control and weight loss [18]
Patientcentered considerations Eligibility and benefit must be weighed against individual comorbidities, preferences, and treatment burden
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Because of that, bioavailability is low (around 0.4 to 1%), so doses look different than injection doses, but the mechanism (slowing stomach emptying, increasing satiety, and promoting weight loss) remains the same
Most people considering alternating are doing so because their weight loss has stalled
It brings new hope to people who want to find effective and lasting ways to manage their weight