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Patients should rotate sites, preferred injection sites include the: Abdomen Thigh Upper arm Safety Profile and Adverse Effects to Watch For Common adverse effects mirror those of the GLP-1 receptor agonist class and are primarily gastrointestinal

They act like glucagon, an endocrine hormone from the pancreas, to mediate weight loss and cause appetite suppression effects

The benefits of semaglutide injections are numerous, including improved blood sugar control, reduced appetite, and significant weight reduction

The primary evidence-based interventions remain: Weight loss through caloric restriction and increased physical activity (target 710% body weight reduction) Dietary modification , including reduced sugar and saturated fat intake Management of associated conditions such as diabetes and dyslipidaemia Alcohol : for NAFLD, keep within UK low-risk drinking guidelines (no more than 14 units per week, ideally less or none)

But for now, the NHS only approves semaglutide for type 2 diabetes and weight loss in people with obesity

Mayer LD, Bally MB, Hope MJ, Cullis PR