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A thorough medical evaluationincluding metabolic screening, contraindication assessment, and baseline biomarker measurementshould precede initiation to ensure safety and appropriate monitoring

In agreement with histological staining, mRNA levels of several markers, including Mmp13 , Timp1 , Tgf and Col3a1 were significantly upregulated in both male and female PBS-treated SKO mice when compared to the PBS-treated WT group ( Figures 3E, F )

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