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1 Lillys Phase 2 trial found that starting at 2 mg rather than 4 mg reduced nausea and vomiting during the stepping-up phase, which is why every Phase 3 trial uses a slow stepwise dose schedule

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Semaglutide is also available as an oral pill, which may help those who are averse to injections

Autophagy (2021) 17(9):205481

& Hannon, G