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These include so-called classical disorders like propionic academia (OMIM 606054) (53), various urea cycle disorders (89), and Sanfilippo syndrome (OMIM 252900, 252920) (90), as well as rarer disorders like succinic semialdehyde dehydrogenase deficiency (OMIM 271980) (91) and branched-chain ketoacid dehydrogenase kinase deficiency (OMIM 614901) (92)
The maximum lipolytic capacity has been shown to be reduced in adipocytes isolated from obese subjects compared with adipocytes from nonobese control subjects following stimulation with the phosphodiesterase-resistant cAMP analogue dibutyryl cAMP (65)
Avoid using strong exfoliants or lightening agents together unless advised by a dermatologist
Sue M, Yajima S
M.BalbinotK
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