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Research has documented modulation of nitric oxiderelated processes, reduction of oxidative damage, and suppression of neuroinflammatory responses

13, 2022, Vanegas JC, Afeiche MC, Gaskins AJ, et al

Interesting data regarding the potential anti-cancer activity of pioglitazone come from studies performed with a transgenic mouse model characterized by a PAX8-PPAR fusion protein (PPFP) (found in 30% of follicular thyroid carcinomas)

Therefore, regardless the clinical heterogeneity or underpinning genetics, the different forms of PD share a common etiology in mitochondrial dysfunction and oxidative stress

Carter, W