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Fujimoto, Y., Oka, A., Omoto, R

a Cochrane review that pooled and graded the trials is the strongest, even when unflattering

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They found that genetically reducing mast cells in mice completely prevented osteoarthritis

Whilst loss of the normal SOD1 antioxidant enzymatic activity was initially proposed as a cause of neurodegeneration, further research implicated gain of a toxic function instead (Hu et al., 2003)

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