Gallbladder events rise modestly, especially with rapid loss. Less common signals include skin dysesthesia, which is now on the label, and a small thyroid-cancer association in two population studies with a tiny absolute event rate. Depression and suicidality remain unproven
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Results were reportedly submitted to ClinicalTrials.gov on May 23, 2016, but the study itself is listed as canceled, which indicates the study sponsor or investigator recalled a submission of study results before quality control review took place
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This is a formidable barrier to research exploring its systemic effects via oral delivery
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