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Proceed with caution: promising inflammation benefits must be balanced against potential worsening of IBD symptoms. For patients struggling with both UC and obesity, experts suggest a thorough approachthe weight management benefits of GLP-1 agonists might indirectly improve UC outcomes by reducing inflammatory markers associated with excess weight

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The FDA was criticized for a slow response, but eventually took a clear stance against this practice and, in cooperation with Justice, started enforcing the rules in 2025

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