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Parent drug accumulated in plasma Greater hERG channel blockade Excessive QT prolongation The Fatal Outcome: Torsades de Pointes (TdP) Excessive QT prolongation predisposes the myocardium to early afterdepolarizations (EADs), which can rapidly progress to: Torsades de Pointes (TdP) Ventricular fibrillation Sudden cardiac death Key Pharmacovigilance Lesson A drug can be highly effective yet become life-threatening when metabolic pathways are disrupted

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Research is ongoing

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