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Traditional medications such as antihistamines, epinephrine, and glucocorticoids are generally not very effective because the underlying mechanism is driven by the accumulation of bradykinin rather than histamine

Other studies have noted similar benefits of metformin therapy (70,71)

"This is achieved by the drug acting on the part of the brain called the hypothalamus, which tells us to feel hungry

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Indian J Pathol Micr 63:570574