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A healthy diet, regular physical activity, weight management (if appropriate), and smoking cessation all contribute significantly to glucose control and reduce cardiovascular risk

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In practical terms, preservation usually requires: Resistance training at least two times per week Protein intake between 1.2 and 1.6 grams per kilogram of body weight per day Without these inputs, weight loss may still occur, but a larger proportion of that loss may come from lean tissue rather than fat

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Extrapolating from other GLP-1 medications, long-term treatment appears necessary for maintaining benefits in most people