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The reason for the long wait is unclear, but it may be telling that the company that initially developed PT-141 (King Pharmaceuticals) was acquired in 2010 by Pfizer, which famously manufactures Viagra and had a vested interest in keeping PT-141 off the shelves until after Viagras patent expired in 2020

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Yet here, too, efforts to minimize effects have proven equal to these difficult tasks

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in HT-1080 cancer cells where treatment with erastin did not cause mitochondrial ROS production 24

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