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Unable to physically see their GP, NHS clinics up and down the country moved their patients off B12 injections to daily oral cyanocobalamin (B12 tablets) on the advice of the British Society of Haematology (GB News is yet to get a response after repeated attempts to contact the BSH)

Statistical comparisons were conducted using the MannWhitney U-test in Prism version 8 (GraphPad Software, CA, USA)

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However, as it sounds like you agree, it's pretty clear that as insulin levels go down IGFBP-3 goes up...sorry, as IGF binding protein 3 goes up...maybe it's worth me taking a moment why that matters

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Trichoplusia ni cell pellets were suspended in 30 mM HEPES (pH 7.4), 50 mM NaCl, 5 mM CaCl 2 , 2 mM MgCl 2 supplemented with protease inhibitors (REF118361 45001, Roche) and benzonase (Merk Millipore)