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At therapeutic doses, tirzepatide has shown greater weight loss outcomes in head-to-head trials

Combining glucagon-receptor agonism with GLP-1/GIP agonism would seem to work against itself

Your digestive system can break down peptides before theyre absorbed

Medicare currently doesnt cover GLP-1s for obesity alone, only for specific approved conditions like type 2 diabetes, cardiovascular disease and obstructive sleep apnea

Wang FF, Wu Y, Zhu YH, et al