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Chronic fissure-in-ano: a randomized study comparing open and subcutaneous lateral internal sphincterotomy

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The melanocortin system regulates expression of genes involved in thermogenesis, including uncoupling proteins in brown adipose tissue, contributing to increased energy expenditure independent of physical activity

Activation of this pathway may result in the conversion of ATP (adenosine triphosphate) into cAMP (cyclic adenosine monophosphate)