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Improved compliance: For some people, taking supplements with meals is easier to remember and stick to as a routine

Consent for publication All authors read and approved the final manuscript

It is to be noted that the BCKDH reaction is essentially irreversible in mammalian cells such that BCKA synthesis depends on essential amino acids, BCAAs, due to the lack of BCKAs de novo synthetases

These results indicate that glutathione is critical for both mammalian development and homeostasis

10.1038/s41586-018-0316-7 125 KanarekN.PetrovaB.SabatiniD

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