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Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy

Total body weight loss from drug initiation to 1 year was collected

Most patients experience side effects primarily during the first 4 to 8 weeks and find they diminish as the dose stabilizes

doi: 10.1111/j.1468-2982.2007.01400.x [DOI] [PubMed] [Google Scholar] 57.Frosst P, Blom H, Milos R, Goyette P, Sheppard CA, Matthews R, et al

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Endocrinology 2005;146:206976