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These modifications grant it pharmacokinetic properties absent in peptides oral bioavailability, protease resistance, and efficient blood-brain barrier penetration but also mean its metabolic fate and tissue distribution may differ substantially from peptide-class compounds

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thereby, p53 may target pro-apoptotic genes and promote their expression

[DOI] [PMC free article] [PubMed] [Google Scholar] 125.Matagne V, Rasier G, Lebrethon MC, Gerard A, Bourguignon JP