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Clinical outcome: Mucositis, stomatitis Severe myelosuppression (anaemia, leukopenia, thrombocytopenia) Nephrotoxicity, hepatotoxicity Life-threatening infections, bleeding High-risk groups: Elderly Patients with renal impairment Patients on high-dose methotrexate (oncology use) Concomitant nephrotoxic drugs Advice: Avoid NSAIDs with high-dose methotrexate

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For enhanced glucose control, increase to 1 mg for another four weeks

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