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This leads to the cleavage and translocation of AIF from the mitochondrial intermembrane space to the nucleus, phosphorylation of the histone H2A family member H2AX, mitochondrial release of the death-inducing protein Smac/direct IAP-binding protein with low PI (DIABLO), and inhibition of the anti-apoptotic protein X-linked inhibitor of apoptosis (XIAP)

This effect may lower blood pressure and reduce excessive sympathetic drive in HF

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J Biol Chem 276(49):4667146677 Gromada J, Franklin I, Wollheim CB (2007) Alpha-cells of the endocrine pancreas: 35 years of research but the enigma remains

Both short-term heat waves and persistent moderate temperatures can lead to irreversible damage or cell death

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