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41 Experimental Studies Injury Type B1 Experimental studies have shown that herniation of the nucleus pulposus (NP) through the defect annulus fibrosus (AF) triggers a series of biomechanical and biological responses

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Similarly, ghrelin normally counteracts leptins trophic effects on these regions and a change in the timing or magnitude of the expected progressive elevation in plasma ghrelin can also disrupt this development (Grove and Cowley, 2005)

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