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Thus, compared to other amino acid incorporation events, Sec incorporation may be less efficient, in part, due to limitations in the availability of cofactors involved in normal Sec-translation and the relative efficiency of normal translation termination events that occur at UGA stop codons

Geriatric Use In elderly patients, it is recommended that the dosage be limited to the smallest effective amount to preclude the development of ataxia or oversedation (2 mg to 2.5 mg once or twice daily, initially to be increased gradually as needed and tolerated)

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topical formulations have established safety profiles in cosmetic use