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MC4R desensitization requires 714 days of consistent exposure at a tolerable dose starting high does not accelerate this timeline, it only increases adverse event frequency
10.1016/B978-0-08-101995-5.00021-0 205.Gulfam M, Sahle FF, Lowe TL
That balance looks different for everyone
Diabetes Mellitus
In the LEADER study with liraglutide, in the evaluation of cardiovascular events [n = 9340 patients, 50 years with established cardiovascular disease (coronary event, cerebrovascular event, or peripheral vascular disease), stage 3 chronic kidney disease, or chronic heart failure according to New York Heart Association class II or III or 60 years with at least one cardiovascular risk factor (CVRF)], liraglutide demonstrated a significant reduction in MACE by 13% at the expense of a reduction in cardiovascular mortality