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Finally, visfatin exacerbates hepatic fibrosis in a steato-hepatitis mouse model, where it enhances the expression of fibrosis markers such as SMA, CTGF, TIMP-1, collagen 12, collagen 32, fibronectin, and vimentin in liver [188]

Jundishapur J Chronic Dis Care

Patients with cardiovascular contraindications to phentermine, or who cannot tolerate stimulant-based medications, may be candidates for orlistat as an alternative approach

TRIUMPH-4 showed retatrutide improves risk factors that predict fewer cardiovascular events, but a dedicated outcomes trial is required to prove actual reduction in heart attacks and strokes

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Microbiome 6:221