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If side effects worsen after switching to split dosing, it may indicate a measurement error resulting in inadvertently higher individual doses, or it may suggest that your side effects are not primarily driven by peak concentration
[DOI] [PMC free article] [PubMed] [Google Scholar] 171.Mac Nair C.E., Nickells R.W
Small means that the results could be skewed by a few outlier responders
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[2] Falutz, J., et al
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