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Since that COVID-19 exhibits unusual symptoms including GSH depletion, GPX4 inactivation, abnormal iron metabolism, and elevation of PUFA peroxidation by reactive oxygen species, it is possible that SARS-CoV-2 might cause ferroptosis in the dopaminergic neurons, which would then contribute to PD
Glutathione neutralizes these harmful free radicals, preventing dullness and premature ageing
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This trend persisted in taf12L/ mutant backgrounds, where both Taf12L and Taf12 showed poor TET -driven expression (Figure S2A)
2013;19(13):1539-1605.[DOI] 3
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