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Oral semaglutide (Rybelsus) already exists for diabetes, with daily doses of 3, 7, or 14 mg compared to the weekly injectable range of 0.25-2.4 mg

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Although baseline heterogeneity was observed, the independent association of treatment with outcomes was confirmed in adjusted analyses

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Here is how to think about it clearly: Choose tirzepatide if: Maximum weight loss is your priority, you have insulin resistance or a high BMI, you previously plateaued on semaglutide, or your insurance covers Zepbound or Mounjaro