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Conversely, stages of a womans life, such as adolescence, perimenopause and menopause, that are associated with reduced estradiol, are also associated with weight gain

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However, the long-term consequences of sustained, supraphysiological TrkB activation remain unknown

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Type 2 diabetes with neuropathy: Forty-eight patients with moderate to severe small fiber neuropathy-induced chronic pain received daily subcutaneous injections of ARA-290 at 4 mg or placebo for 28 days

Rotenone induces PD-like motor symptoms such as muscular rigidity, bradykinesia, and the aggregation of -synuclein (Betarbet et al., 2010)