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Actual dosing decisions depend on provider evaluation, patient tolerance, and treatment goals

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Read together with the failed fosgonimeton trial, the takeaway is that the human-relevant evidence base for this class is both thin and, where it touched humans, negative

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We verified the impact of ACTL6A on GSH synthesis and confirmed that ACTL6A KD led to reduced expression of certain genes (GCLC, GPX2, GPX4, SLC7A11, SLC1A5, GSS, GLS, etc.) involved in the GSH synthesis pathway (Supplementary Fig