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3) BDNF is not only released by glutamatergic presynaptic terminals and also acts as a retrograde messenger to inhibit the excitation of inhibitory dorsal horn neurons from the postsynaptic membrane (168)

The magnitude of improvement in cardiorespiratory fitness is clinically important

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Many other studies [13, 38, 45, 65, 121, 126, 130, 137], followed the same approach, while others [8, 31, 36, 57, 86, 103, 109, 140, 141], added normalisation to the pipeline to map the extracted ADEs to codes in the commonly used ontologies such as SNOMED-CT or UMLS

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