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The level of murine double minute 2 (MDM2) was significantly upregulated in neurons of SOD1 G93A transgenic mice

Finally, mechanistic studies showed that the activation of nuclear factor-kappa B (NF-B) was involved in the SGNs damage caused by peroxynitrite and that GPX1 protected SGNs against peroxynitrite-induced damage, at least in part, via blocking the NF-B pathway activation