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Rheumatologists often adjust allopurinol doses higher than 300mg when needed to reach uric acid goal, although the literature on higher doses of allopurinol is limited

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Increased natural killer (NK) cytotoxicity 2x (at 3 months (1,000 mg/day))

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Furthermore, they are chemically unstable and highly sensitive to external factors such as light, heat, oxygen, and pH fluctuations, leading to substantial degradation during processing, storage, and gastrointestinal transit (915)

England P, Wehenkel A, Martins S, Hoos S, Andre-Leroux G, Villarino A, Alzari PM: The FHA-containing protein GarA acts as a phosphorylation-dependent molecular switch in mycobacterial signaling