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Creatine users on semaglutide lost less muscle and strength over 12-16 weeks compared to non-users
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J Biol Chem (2014) 289:1524458.10.1074/jbc.M113.540633 34 TurpaevKT
Formation of hexa- and decadepsipeptides via NRPS misoperation is key to form the isocereulides E, F and G, whereas peptide assembly in the biosynthesis of isocereulides A-D corresponds well to that of cereulide differing that L- O -Val is substituted by L- O -Leu (isocereulide A), L-Val by L-Ala (isocereulide D), D-Ala by D-Ser (isocereulide C) and D-O-Leu by D-O-Val (isocereulide B) due to a relaxed substrate specificity of the A domains and/or an inefficient proof reading by CesT
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