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This pathological stretch also activates NF-B, promoting the secretion of pro-inflammatory cytokines such as IL-6/8 and the expression of CD40 and VCAM-1, driving immune cell recruitment and contributing to atherosclerosis progression [214]

45 Tirzepatide Tirzepatide is a 39-aa peptide conjugated with C20 fatty acids (MW: 4813 g/mol) (Figure 1H)