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Hair follicle response takes time

Both approaches have valid applications depending on the research context

doi: 10.1002/art.27650 57 MoschovakisGLBubkeAFriedrichsenMRistenpartJBackJWFalkCSet al

Doseinjury relationship: When NAPQI production exceeds glutathione supplythrough high single doses, high cumulative daily doses, or impaired conjugation/low GSHcentrilobular hepatic necrosis can occur

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This presystemic nasal metabolism is a primary barrier and is distinct from intestinal first-pass metabolism