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The bulk of OA research remains preliminary

Cell surface biotinylation further showed ZIP8 and ZIP14 on both membranes of human brain microvascular endothelial cells (hBMVECs), with ZIP8 more abundant apically and ZIP14 basolaterally, though not statistically significant (Steimle et al., 2019)

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The secondary endpoint included changes in glucose, insulin, HOMA-IR, blood pressure, lipid profiles, uric acid, free fatty acids, hepatic profile, and the sensation of fatigue and hunger