In AWARD-1, the once-weekly injectable GLP-1 agonist demonstrated superior glycemic control compared with twice-daily exenatide (Byetta) in type 2 diabetic patients not adequately controlled with full-dose metformin and pioglitazone
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Lower concentrations like 1 mg/mL allow for easier measurement of small doses but require larger injection volumes
To support healthy glutathione levels: Ensure adequate protein intake with sulfur-rich foods (eggs, poultry, fish, cruciferous vegetables) Meet choline requirements (only 11% of pregnant women achieve this) Supplement with vitamins C and E to support glutathione recycling Ensure adequate B vitamins (B6, B12, folate) for methylation support Minimize environmental exposures (chlorinated water, VOCs, formaldehyde) Consider N-acetylcysteine (NAC) supplementation under healthcare provider guidance Work with a functional medicine practitioner to optimize metabolic health before and during pregnancy When considering acetaminophen: Discuss your individual risk factors with your healthcare provider Consider whether you have PCOS, conceived via IVF, have gestational blood sugar issues, gallbladder issues, or choline deficiency Understand that "safe" doses assume normal detoxification capacity If you have compromised glutathione status, even therapeutic doses may pose risk The danger isn't acetaminophen as a moleculeit's the toxic metabolite created when vulnerable populations with impaired detoxification capacity try to process it
Pisano as senior author
Our IHC studies on human and mouse islets confirmed our DART-Seq findings that liraglutide increases bihormonal insulin + glucagon + cells
