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PBMCs and subpopulation isolation Human PBMCs were isolated from fresh donor blood samples by gradient centrifugation using Ficoll-Paque (GE Healthcare, Madrid, Spain) following the manufacturers instructions

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LCMS analysis of TCA cycle metabolites showed that ABHD11 loss resulted in 2-OG and 2-HG accumulation as expected 16,23 , and in line with the effects of ML226 (Fig

Some people develop bile acid diarrhoea after gallbladder removal, which may require assessment and possibly treatment with bile acid sequestrants if symptoms are troublesome

After a successful career as a Navy plastic surgeon, Dr

The mitochondria further help in the conversion of fatty acids to energy