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459,460 The anti-inflammatory effects of GLP-1RAs contribute to the attenuation of atherosclerotic plaque lesion development through various mechanisms

Gallstones are also linked to increased risk of certain cancers and cardiovascular diseases

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It could contribute to curbing the increase of obesity-related illnesses, which chop off as many as seven years from the life span

Clinical trials are underway, including multiple in Phase 3, that will be able to answer more questions about retatrutides safety

Clinically, GLP-1RAs could lead to an improvement in cognitive function, which is often found to be impaired across several conditions such as psychosis 240 and mood disorders 241 , eventually leading to an overall benefit as observed in some of the included studies (Tables 4 and 5)