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Patients with a personal or family history of cancer, those who are pregnant or breastfeeding, or those taking immunosuppressants should discuss individualized risk-benefit considerations with their provider

As mentioned above, serotonin signaling is a potential therapeutic target in IBS (53)

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These flavonoid metabolites exert estrogen-like effects and can ameliorate postmenopausal osteoporosis by modulating estrogen receptor (ER)-mediated signaling pathways (Messina, 2016