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We previously demonstrated that the L585 residue of albumin promotes a structural destabilization in three regions of the C-terminal DIII domain, and thus, induces an intra-domain flexibility required for efficient FcRn binding 60

doi: 10.3389/fmed.2026.1752341 Received 23 November 2025 Revised 04 April 2026 Accepted 10 April 2026 Published 29 April 2026 Volume 13 - 2026 Edited by Wei Liu, Huazhong University of Science and Technology, China Reviewed by Jheng-Yan Wu, Chi Mei Medical Center, Taiwan Jennifer Teske, University of Arizona, United States Updates Copyright 2026 Fang, Zhu, Rao and Liu

Storage Instructions Keep the pre-mixed vial refrigerated at 28 C and protected from light cyanocobalamin degrades on light exposure, which is why vials are often kept boxed [2]

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