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GCGR activation stimulates hepatic glucose production between meals, increases lipolysis and fatty acid oxidation in the liver, elevates basal energy expenditure, and promotes thermogenesis

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Taking a dose too early may slightly increase the risk of side effects such as nausea, vomiting, or abdominal discomfort, but is unlikely to affect the overall effectiveness of treatment

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While these strategies remain experimental, they offer hope for patients with recurrent or refractory disease (Plotkin & Blakeley, 2022)